{"id":8186,"date":"2020-12-23T15:48:04","date_gmt":"2020-12-23T14:48:04","guid":{"rendered":"https:\/\/tecnologiehosting.it\/?p=8186"},"modified":"2022-10-17T12:20:02","modified_gmt":"2022-10-17T10:20:02","slug":"diagnosi-precoce-tumore-pancreas-natimab","status":"publish","type":"post","link":"https:\/\/bio4dreams.com\/en\/diagnosi-precoce-tumore-pancreas-natimab\/","title":{"rendered":"NatiMab: un kit per la diagnosi precoce del tumore del pancreas"},"content":{"rendered":"\n

Tumore pancreatico: poco conosciuto, difficile da trovare e da curare<\/h2>\n\n\n\n

Il tumore del pancreas<\/strong> \u00e8 uno dei tumori con la peggiore diagnosi e minore sopravvivenza<\/strong>; \u00e8 quarto tra le cause di morte per tumore.1<\/sup><\/p>\n\n\n\n

Purtroppo si sa ancora poco della sua biologia. In fase precoce non d\u00e0 segni particolari<\/strong> oppure d\u00e0<\/strong> disturbi piuttosto vaghi<\/strong>, che possono trarre in inganno pazienti e medici.<\/p>\n\n\n\n

Contro questo tumore si pu\u00f2 intervenire con l\u2019asportazione chirurgica, ma solo in una piccola percentuale di pazienti (meno di 1 su 5).1<\/sup> <\/p>\n\n\n\n

Infatti, spesso la diagnosi viene fatta quando ormai la malattia \u00e8 in fase avanzata<\/strong>, con metastasi, e quindi difficile da trattare.<\/p>\n\n\n\n

Questo spiega il basso tasso di sopravvivenza<\/strong>, circa 1 paziente su 12 a cinque anni dalla diagnosi.1<\/sup><\/p>\n\n\n\n

Per alcuni sottotipi di tumore pancreatico sono disponibili alcuni farmaci<\/strong> e altri sono in corso di sperimentazione, ma la loro efficacia dipende fortemente dal tempismo<\/strong> di identificazione della patologia.<\/p>\n\n\n\n

La sfida<\/strong>, quindi, \u00e8 trovare un sistema per diagnosticare il tumore precocemente<\/strong>, quando \u00e8 ancora nelle fasi iniziali di sviluppo, cio\u00e8 di piccole dimensioni e non ancora diffuso.<\/p>\n\n\n

\n
\"\"
Immagine di tessuto tumorale pancreatico ottenuta tramite microscopia confocale.<\/figcaption><\/figure>\n<\/div>\n\n\n

Tre marcatori per \u201cscovare\u201d il tumore del pancreas<\/h2>\n\n\n\n

I marcatori tumorali<\/strong> sono delle molecole rilevabili nel circolo sanguigno che possono indicare la presenza di un tumore<\/strong>. Vengono rilasciati dalle cellule maligne o dell\u2019organismo in risposta al tumore stesso.<\/p>\n\n\n\n

Pi\u00f9 sono specifici per un tipo di cancro, pi\u00f9 sono utili per la sua diagnosi precoce, per seguirne il decorso e la prognosi.<\/p>\n\n\n\n

Per il tumore del pancreas \u00e8 gi\u00e0 utilizzato un marcatore<\/strong>, una proteina chiamata CA 19.9<\/strong>, che tuttavia non \u00e8 sempre rilevabile e quindi non sufficiente, da solo, per una diagnosi accurata.<\/p>\n\n\n\n

Il gruppo di ricerca di NatiMab Therapeutics<\/strong>, realt\u00e0 fondata nel 2008, ha individuato due nuovi potenziali marcatori tumorali<\/strong> (alfa-enolasi ed ezrina) espressi dall\u2019adenocarcinoma pancreatico duttale, uno delle forme pi\u00f9 aggressive e letali.<\/p>\n\n\n\n

L\u2019idea, in fase di studio, \u00e8 sviluppare un kit diagnostico che, <\/strong>con una semplice biopsia liquida non invasiva, riesca a rilevare gli anticorpi circolanti contro questi due marcatori insieme al CA 19.9<\/strong>. Ci\u00f2 migliorerebbe la capacit\u00e0 della diagnosi precoce del tumore pancreatico, permettendo di trattarlo per tempo.<\/p>\n\n\n\n

Lo stato dell\u2019arte<\/h2>\n\n\n\n

NatiMab vanta due brevetti negli Stati Uniti e in Europa per lo sviluppo di kit diagnostici per dosare i marcatori alfa-enolasi ed ezrina e sta attivamente lavorando per la loro ottimizzazione.<\/p>\n\n\n\n

\u201cScoprire le tracce del tumore pancreatico il piu presto possibile, per curarlo meglio.\u201d<\/em><\/p>Francesco Novelli<\/strong>, Project Coordinator and NatiMab shareholder<\/cite><\/blockquote>\n\n\n\n

Scopri di pi\u00f9 su NatiMab<\/a> e le altre realt\u00e0<\/a> del nostro ecosistema.<\/p>\n\n\n\n

1<\/sup>Aiom. I numeri del cancro in Italia 2019<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Il tumore pancreativo viene spesso scoperto troppo tardi. NatiMab, PMI innovativa, sta sviluppando un kit diagnostico per individuarlo precocemente.<\/p>\n","protected":false},"author":2,"featured_media":11871,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[16],"tags":[],"class_list":["post-8186","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-portfolio"],"acf":[],"yoast_head":"\nNatiMab: un kit per la diagnosi precoce del tumore del pancreas \ud83e\uddeb<\/title>\n<meta name=\"description\" content=\"Il tumore pancreativo viene spesso scoperto troppo tardi. 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